ari CHIKURU Chakavanzika kuti BIG Pharma anofunga kuti wakapusa kuti unzwisise!
Zvinodhaka, mbeva, DNA, uye Big Pharma huori
Updated:
verenga
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Ona zvimwe
[Nhamba dzepamutemo: 2 zvinyorwa] [Gwaro redare repamutemo: 1 tsime] [Zvakananga kubva kutsime: 1 tsime] [Chiremera chepamusoro uye mawebhusaiti akavimbika: 2 zvinyorwa]Yaimbova yakachengeteka uye inoshanda, ikozvino yafa. Nei zvinodhaka zvakawanda kwazvo zviri kurangarirwa?
By Richard Ahern - Tinofanira here kuvimba nehupofu kuti mishonga yese yakachengeteka uye inoshanda nekuti FDA inodaro? Sainzi iri seri kweindasitiri yemishonga inogara yakakwana here?
Muna 2022, iyi ndiyo mibvunzo yakakosha yatinofanira kubvunza!
Munyaya ino, tichapindura mibvunzo iyoyo inokosha.
Tiri kurarama munguva isati yamboitika a dambudziko renyika apo mubvunzo wekushanda kwejekiseni uye kuchengetedzwa kwemishonga hauna kumbobvira wanyanya pamusoro pepfungwa. Vazhinji vedu tinobvunza kuchengetedzwa kwemishonga, majekiseni, uye marapiro, asi kuwana humbowo hwakaoma hwekutsigira chero chinhu hazvigoneke kune nhengo yeruzhinji.
Muchokwadi, tave panguva yekuti pese kana mumwe munhu akada kubvunza kushanda kwezvinodhaka kana kuchengetedzwa kwekudzivirira, zvinowanzoitika kuona munhu iyeye achirambidzwa "kuparadzira nhema" pasocial media.
Kana mushonga wabvumidzwa neFDA, hurumende uye Big Tech inoda kuti tisambofa takabvunza kuchengeteka kwayo. Avo vanotsunga kubvunza "sainzi" yekuongororwa kwemushonga vanodaidzwa sevanorangana theorists.
Uye zvakadaro…
Pave paine zviuru gumi nezviviri nemazana manomwe nemakumi masere nenomwe ekuyeukwa kwezvinodhaka zvakapihwa neFDA kubvira 12,787.
Paavhareji, 1,279 mishonga inorangarirwa gore rega rega. United States inotungamira nzira nekuwanda kwe12,028 inoyeuka, nyika ine yechipiri inonyanya kuyeuka iCanada, ine madiki 554 akarangarira zvinodhaka.
Iwo manhamba anofanirwa kukuvhundutsa iwe kune yako musimboti, yega yega yeiyo FDA inorangarira i "huu, ndine hurombo kuti takanganisa" neFDA.
Ichi chinyorwa chakaratidzwa chine chinangwa chekutsanangura chikonzero chiri shure kwehuwandu hukuru hwekuyeuka kwezvinodhaka.
Zvakawanda chinyorwa ichi chine chinangwa chekuratidza kuti hausi "anti-sainzi" kana iwe ukabvunza sainzi kuseri kwekuongororwa kwemishonga.
Iyi haisi dzidziso yekurangana, ichi ichokwadi chakaburitswa nesainzi kuti Big Pharma yakatsvaira pasi pegumbo.
Mashoko anovhiringidza anoratidzwa pasi apa akadzvinyirirwa nevesainzi uye hapana kutaurwa nezvazvo kunogona kuwanikwa munhau dzemazuva ese. Nehurombo, nekuti sainzi kuseri kwekuyedzwa kwemishonga kunoda kunzwisisa kune musoro kwebiology, tisingataure imwe pfungwa, vangangove vatori venhau vazhinji havanzwisise, vanotya zvakanyanya, kana kungoita nungo kuti vataure nezvazvo. Izvi zvinoitawo kuti zviomere veruzhinji kuti vanzwisise kuti chii chiri munjodzi, izvo zvingangoita kuti ruzivo urwu rurambe rwuri mumumvuri kwenguva yakareba.
Uyezve, chikonzero chakanyanya kuipa ndechekuti chokwadi chekuti zvinodhaka zvinoedzwa sei zvinokuvadza Big Pharma nekuti inokanda kusava nechokwadi nezvekuchengetedzwa kwezviuru zvemishonga, vaccines, uye kurapa kwakato“tenderwa” kushandiswa nevanhu. Tichitorwa zvakadzama, takakwanisa kuona kuedza kukuru kuongororazve mishonga iyi ine nhamba yakakura iri kurangarirwa.
Iyo Big Pharma ine tsika yakakwana kuisa hutano pamusoro pepurofiti?
Kashoma!
Kusvikira kukanganisa kwakaipisisa nekuchengetedzwa kwezvinodhaka kwave kutariswa zvakanyanya, isu hatisi kuona chero kuedza kuri kuitwa, asi ibasa reavo vanoziva kuti varambe vachipopota nezvazvo kusvikira makambani ezvinodhaka apa humbowo hwakasimba hwekuti yakagadziriswa uye matanho akakodzera ari mukati. nzvimbo kudzivirira matambudziko mune ramangwana.
We at LifeLine Media vari kuzovhenekera kuwanikwa uku uye nekuzviita nenzira iyo munhu wese anogona kunzwisisa, zvisinei nekunzwisisa kwako kwesainzi. Isu tine chinangwa chekuita kuti ruzivo urwu ruwanikwe kune wese munhu, pasina jargon yesainzi, kuitira kuti mushure mekuverenga izvi unzwisise zvakajeka matambudziko ekuongororwa kwezvinodhaka uye kuchengetedzwa kwemishonga.
Hupenyu huri panjodzi…
Muchidimbu, kuwanikwa uku kune chekuita nekukanganisika kwemajini mumakonzo erabhoritari, zvichida semugumisiro wekubereka kwehusungwa, zvinoreva kuti nzira yavanodyidzana nayo nemishonga haisi yechisikigo. Zvakatonyanya kukosha, izvi zvinomutsa kusahadzika nezve kuyedzwa kwese kwemishonga pamhuka dzakazvarwa mumarabhoritari.
Wagadzirira here kudzidza izvo Big Pharma inofunga kuti wakapusa kuti unzwisise?
FDA yakabvumidza mishonga yakayeukwa
Tevedzera sainzi
Kangani pawakanzwa vakuru vehurumende vachiti "tevera sainzi" kana zvasvika kune zvinodhaka uye vaccine kubudirira?
Saka, ngati “tevedzei sainzi”!
Heino mhedziso yekukurumidza yeiyo biology kuseri kwezvatiri kutaura nezvazvo, kana iwe uchitonyatsoziva izvi inzwa wakasununguka svetuka chikamu ichi, asi iyo yakakosha kumashure kune yakakosha nyaya yekuchengetedzwa kwekurapa.
Ngatinyurirei…
Tora sero kubva mumuviri wako utarise pasi pemaikorosikopu ine simba. Iwe uchaona iyo huru sero muviri une diki, rakakomberedzwa blob mukati, inonzi cell nucleus. Mukati memukati mese mune zvenyu DNA, yako yakazara uye yakasarudzika genetic profiles iyo inonyora "iwe".
DNA ndiyo kodhi yehupenyu.
DNA inomonyaniswa uye inopetwa kuita mapaya emakromosomes. MaChromosomes akakamurwa kuita zvikamu zveDNA inozivikanwa semajini, uye jini rega rega rinosarudza hunhu chaihwo. Kune mazana kusvika kuzviuru zvemajini pakromosome.
Chimbofungidzira musimboti wacho seraibhurari (diki rine mabhuku 46 evanhu); machromosome ibhuku rimwe nerimwe, uye majini ndiwo ndima dziri mumabhuku iwayo.
Masayendisiti anoda zvinhu zvakarongeka, saka vakanyora nhamba imwe neimwe yemakromozomu. Kuti ndikupe mimwe mienzaniso, chromosome pair one ine geni rinotara hukuru hwehuropi hwako. Makromosome epabonde (maviri makumi maviri nematatu) ane majini anotarisisa kuti uri murume here.
Vanhu vane 23 mapeya echromosomes uye makumi mana nematanhatu pamwe chete.
Mhando dzakasiyana dzine nhamba dzakasiyana dzemakromosomes. Semuenzaniso, mbeva dzine mapeya makumi maviri emakromozomu uye anosvika makumi mana.
Rangarira, machromosomes anongounganidzwa zvidimbu zveDNA…
DNA inokanganisa hunhu hwechisikwa inodaidzwa kuti coding DNA nekuti inonyora mapuroteni anosika chipenyu ichocho (isu takagadzirwa nemapuroteni). Majini ari kunyora DNA. Kana coding DNA ikakuvadzwa, inogona kukonzera kukuvadza kukuru kune chipenyu nekuti mapuroteni asiri iwo anogadzirwa.
Unorangarira kubva kukirasi yebiology kuti masero anogara achipatsanura?
Nguva yese sero parinopatsanura rinofanira kukopa DNA yese iri mukati memwoyo wayo. Panguva kupatsanurwa kwemasero, kunyora DNA kunofanira kuchengetedzwa kudzivirira kuchinja kune ngozi.
Rambira neni, izvi zvichave zvine musoro munguva pfupi!
Haasi ese maDNA makodhi emapuroteni, kune zvakare isiri-coding DNA iyo isingakodzeri chero chinhu; saka inowanzonzi DNA isina chinhu.
Junk DNA haina maturo!
Magumo emakromosome akaumbwa nejunk DNA uye anodanwa telomeres. Telomeres inodzivirira iyo coding DNA yemakromosomes kubva mukukuvadzwa panguva yekuparadzaniswa kwesero.
Fungidzira izvi:
Mamiriro uye kushanda kwematelomere kwakafanana nepurasitiki inoperera tambo yebhutsu inodzivirira kubvaruka.
Matelomere akafananawo nefiyuzi pabhomba.
Dzakafanana nefiyuzi nekuti pese panopatsanurwa sero uye makromosome aro akakopwa rinorasikirwa nechikamu chidiki cheDNA. Uku ndiko kusingadzivisike mhedzisiro yemugadziriso uri kuseri kweDNA replication. Naizvozvo, kureba kwetelomere uye hupenyu hurefu hwakabatana zvakananga; patinenge tichikura matelomere anosakara nekupfupika, asi iyo coding DNA chikamu chekromosome chinodzivirirwa.
Vana vacheche vane matelomere marefu, asi vakweguru vane matelomere mapfupi zvikuru. Marefu telomere ane basa revechidiki uye nekukurumidza kugadziriswa kwetishu.
Chii chinonzi telomere? - Telomeres uye kuchembera
Telomeres uye kenza
Telomere kureba uye kenza zvakare yakabatana.
Sero rega rega rinogona kungopatsanura uye kudzokorora DNA yaro kakati wandei matelomere asati asakara (fuse yapiswa) - panguva ino, DNA yekukodha yave kuburitswa. Izvi zvinozivikanwa se Hayflick muganhu. Masero mazhinji anogona kupatsanura kanokwana ka40-60 asati asvika pamuganhu uyu.
Kana iyo DNA yekodhi yatanga kukuvadzwa, shanduko ine njodzi inogona kuitika iyo inogona kuguma negomarara kana sero rikaramba richipatsanuka.
Kuti adzivise izvi, masero ane “yakavakirwa-mukati mekudzora mashandiro” inoamisa kupatsanura kana telomere fuse yaenda. Iyi nzira inodaidzwa muzvideoXNUMX. Kana sero rave senescent, rinomira kupatsanura uye harina charinoita, rakafanana ne "zombie cell".
Ingori hafu yenyaya...
Izvo zvakakoshawo kuti unzwisise kuti coding DNA inogona kukuvara mune dzimwe nzira dzakawanda kubva mutagens, zvakadai semwaranzi yeionizing, zvinhu zvinobudisa mwaranzi, uye mamwe makemikari. Kana sero coding DNA ikakuvadzwa kubva mutagen inogona kuita cancer. Neraki, muganho wayo weHayflick unoidzivirira kubva pakuramba uchidzokorora, inova dziviriro kubva kugomarara. Kana sero rine yakakuvadzwa coding DNA inogona chete kupatsanura 40-60 nguva, izvo zvinodzivirira kubva pakugadzira hofori bundu.
Cancerous tumors mapoka emaseru ane akakuvadzwa coding DNA iyo yakaramba ichipatsanurwa nekusingaperi nekuti kukuvara kwekudzora nzira ye senescence yakamira kushanda nemazvo.
Iko kuvakwa kwesesescent cell ndiko kunoita kuti matissue achembera. Semuenzaniso, kuunganidzwa kwemasero eganda ane senescent ndiko kunotungamirira kuganda rakaunyana uye rakatetepa mukukwegura. Masero anoita senescent anowedzera matishu, inononoka kuzvigadzirisa kubva mukukuvadzwa nekuti masell cell haakwanise kupatsanura nekuzvitsiva.
Mumashoko akareruka, isu tine kutengeserana pakati pekuchembera negomarara!
Rangarira, zvese zvinoenderana neizvi:
Tishu inoumbwa nemaseru ane matelomere akareba inotora nguva yakareba kusvika zera uye inovandudza kubva mukukuvadzwa pamwero wakawedzerwa. Nekudaro, nekuti maseru aya anogona kuramba achipatsanuka, ari panjodzi yegomarara nekuti haana iyo nzira yekudzora kukuvara kweHayflick muganho.
Ko matelomere anobatana sei nekukura kwegomarara?
DAMBUDZIKO nemishonga - The BIG issue
Zvakanaka, saka nei chero yeiyi nyaya kune kuchengetedzwa kwemishonga?
Zvese zvinouya kumakonzo…
Hongu, mbeva!
Masayendisiti akambodavira kuti mbeva dzose semhuka dzine matelomere marefu. Zvakataurwa naKipling naCooke muna 1990 kuti mbeva dzine “Ultra-refu telomeres” idzo dzakanga “dzakakura kakawanda kupfuura dzinenge dziri pamatelomere evanhu.”
Zvavakawana zvaive zvechokwadi asi heino mutsigiri:
Anopfuura makumi maviri emakore apfuura, biologist Bret Weinstein akafungidzira kuti ma telomere akareba-refu aingovepo mumakonzo erabhu akarerwa muutapwa, asi mbeva dzemusango dzaive dzakajairwa kureba telomeres.
Aitaura chokwadi! Uku kwaiva kuwana kukuru!
Izvi zvakasimbiswa mubepa naGreider naHemann (2000), pavakaenzanisa kureba kwetelomere yema lab mbeva nemakonzo emusango. Vakagumisa kuti “Kureba kweTelomere kwaiva kupfupika zvikuru mukati madhiri emusango"!
Mbeva dzeLab dzine matelomere akareba.
Mbeva dzemusango dzine matelomere akareba.
Weinstein naCiszek vanotaurwa mukati iyo reserve-capacity hypothesis (2002 bepa) kuti aya ekupedzisira-akareba matelomere angangove "asingatarisirwe mhedzisiro yekubereka kwenhapwa". Vaitenda kuti mamiriro ezvinhu mumakoroni ekuberekesa, akadai sekuberekesa mbeva pazera diki kuti awedzere kubereka (mbeva dzekuberekesa dzinoregedzwa pamwedzi misere) dzakakonzera shanduko dzisiri dzechisikigo mukureba kwetelomere.
Rangarira kubva kare kuti matelomere akareba akaenzana nekukurumidza kugadziriswa kwetishu?
Hongu, ndizvo chaizvo zvakawanikwa muma lab mbeva sezvakaratidzwa na Alexander, P. (1966). Vakataura kuti, "Chokwadi chinonyanya kushamisa ndechekuti mbeva dzakakura kwazvo (semuenzaniso makore anopfuura 2.5) padzakaurayiwa dzichiri kugona dzinenge dziine zvirwere zvishoma uye dzinenge dzisingaonekwe nemhuka diki" (muna 1966 izvi zvaifungidzirwa kuti nyaya yemakonzo ese).
Aya mbeva dzerabhu dzakaberekeswa muusungwa dzakaramba dzisiri dzepwere, dziine hunyanzvi hwekugadzirisa matishu akakuvadzwa, uye dzaive dzakasimba zvisingaite kukuvara.
Dzaive mbeva dzepamusoro! Asi pane imwe diki yekubata ...
Kudzikira kweiyi kugona kwakawedzerwa kudzoreredza maseru kwaireva kuti mbeva idzi dzainyanya kubatwa negomarara nekuti maseru avo anenge asina kumbobvira asvika senescence! Vakanga vasina nzira yekudzora kukuvara inodzivirira cancer!
Ese aya mbeva dzema lab, kana akabvumidzwa kurarama hupenyu hwawo, aisazofa nekuchembera, asi panzvimbo pezvo, aizofa negomarara.
Hedzinoi nhau dzakaipa:
Aya makonzo ane genetically mutated ari kushandiswa mukuongororwa kwekurapa nekutsvaga!
Kana mushonga wakakonzera kukuvadzwa kwesero ukaedzwa pamakonzo erabhoritari, kukuvara ikoko kwaigona kusaonekwa nekuti mbeva dzinogona kugadzirisa matishu nekukurumidza zvisingaite. Sezvineiwo, nekuda kwema telomere emakonzo ekupedzisira-kureba, kubata kwavo gomarara kungave kwakakwira zvisingaite.
Isu tine mamiriro ekutarisira kushomeka kwekukuvara kwetishu uye kuwandisa kwegomarara.
Izvi zvakapfupikiswa zvakakwana mumhedziso yebepa raWeinstein naCiszek (2002) pavakasimbisa zvinotevera:
“Saka tinofanirwa kufunga zvakare kushandiswa kwezvinhu zvinonzi zvakachengeteka nekuti zvakaratidza kusakuvadza ku'mbeva'. Panguva imwecheteyo, kuongororwa kwekuchengetedza nemakonzo erebhu kunogona kuwedzeredza njodzi dzegomarara, zvichitungamira kune yambiro isina kufanira nezve zvimwe zvinhu zvakakosha. "
Zvinosuruvarisa, hapana akateerera, uye bepa rakavigwa nevesayenzi. Mishonga yaigona kupfuura nemiedzo yekuongorora rodent ine mavara anobhururuka asi muchokwadi ichigona kukonzeresa kukuvara kwetishu.
Mishonga iyi inogona kunge yakagara mukabati yako yemishonga!
Ngatimbozamai zvishoma...
Kuwanikwa kweiyi genetic abnormality muma lab mbeva, sekuburitswa kwa Greider and Hemann (2000) kwakawanikwa muma lab mbeva akapihwa neJackson (JAX) marabhoritari muUnited States. Iyo JAX lab ndeimwe yevatengesi vakuru pasi rose vembeva dzema lab kune vanoongorora pasi rese, kunyanya nyika dzakabatana.
Asi hechino chimwe chinhu chinonakidza kufunga nezvazvo ...
Kuwanikwa uku kunogona kungove kwakanangana neJAX lab mbeva nekuti ndidzo dzakaedzwa Greider naHemann. Kana Jackson lab mbeva ari iwo ega mbeva dzerabhu dzakagadzira aya matelomere akareba-refu, inogona kuve tsananguro yehuwandu hwekurangarira zvinodhaka hwakanyanya muUnited States, tichiona kuti ruzhinji rwevaongorori vekuUS vanopihwa neJackson laboratory.
Chinonyanya kukosha:
Izvi zvinomutsa nyaya yakafara yekurera maprotocol anoshandiswa kune vese mhuka izvo zvinopihwa kune vanoongorora. Kuberekesa chizvarwa mushure mechizvarwa chemarudzi munzvimbo yerabhoritari, uko kusarudzika kwechisikigo kudzvanyirira kusipo kunogona kukonzera kushanduka kusingatarisirwi uye kusiri kwechisikigo.
Pakupedzisira, mishonga yakawanda inogadzirirwa kushandiswa kwevanhu. Vanhu vakashanduka kwezviuru zvemakore mumhoteredzo yechisikigo, kwete marabhoritari.
Kuedza mishonga pamhuka dzakagadzira kuchinja kusiri kwechisikigo kubva mukuberekeswa murabhoritari yakasungwa pasina mubvunzo inzira isina kunaka uye ine njodzi yekuongororwa kwezvinodhaka uye vaccine.
Vanhu havana matelomere akareba-refu uye hatina simba risingaperi rekugadzirisa matishu, asi mimwe yemishonga yatiri kutora tisingazivi yakaedzwa pamhuka dzinodaro!
Ndiyo sainzi yakaora!
Sei mbeva dzichikosha? - Mabhenefiti ekuongorora mhuka pamakonzo madiki
Unogona kunge uchibvunza…
Sei mbeva dzichikosha kana kuongororwa kwezvinodhaka zvemhuka kuchiitwawo pamhuka hombe?
Uku kusanzwisisa kwakajairika. Kazhinji, mishonga yese inoedzwa pamakonzo (nemamwe makonzo madiki), uye kunyangwe paine matambudziko nekushandisa mbeva mukutsvagisa, ivo vanopawo yakasarudzika mukana wekuongororwa kwekuchengetedza zvinodhaka.
Heino chikonzero nei:
Mhuka diki dzinoda mbeva dzakamhanyisa kutenderera kwehupenyu kakawanda nekukurumidza kupfuura mhuka huru nevanhu. Kuti uzviise mumaonero, Dutta and Sengupta (2015) "vakawana kuti gore revanhu rakaenzana nemazuva mapfumbamwe emakonzo".
Mbeva dzinonyanya kubatsira pakutsvaga mhedzisiro yenguva refu yemishonga inogona kutora makore kuti ionekwe pamhuka hombe.
Ichi ndicho chikonzero kuongororwa kwemhuka kuchikosha!
Munguva yekuyedzwa kwemishonga, masayendisiti anowanzo kupa makonzo madiki epamusoro emishonga munguva pfupi. Tarisiro ndeyekuti chero mhedzisiro inogona kunge iri iyo mhuka hombe kana munhu angazosangana nayo nekufamba kwenguva padiki dosi.
Iyi dudziro yehumbowo hwetsvakiridzo kubva kumhuka kuenda kuvanhu haina kupusa, asi mudzidziso, makonzo madiki anobvumira masayendisiti kutarisa mune ramangwana kuti aone mhedzisiro yenguva refu yemushonga.
Funga nezvazvo…
Tora mushonga unokonzera kukanganisa nhengo zvishoma nezvishoma uye zvinotora makore kuratidza. Izvi zvaizopfuura miedzo pamhuka huru dzinoyamwisa asi dzaigona kukundikana pamakonzo nekuda kwehupenyu hwadzo hwekukurumidza.
Iyi ndiyo imwe yemabhenefiti makuru ekuongororwa kwemhuka pamakonzo madiki, nekuti inogona kunge iri nzira yega yekubvisa kukuvara kwenguva refu kunokonzerwa nemishonga.
Mishonga inokuvadza mbeva nekukasira ingangoratidza kukuvara kwenguva refu kwevanhu izvo zvinogona kutora makore mazhinji kuratidza.
Unogona here kunzwa chipikicha ichi chichidhumhana pamwe chete izvozvi?
Kana mbeva dzema lab dzine matelomeres akareba zvisingaite uye dzichikwanisa kugadzirisa kukuvara kwesero nekukurumidza zvakanyanya, iyo modhi yese yekuona mhedzisiro yenguva refu inodonha!
Mishonga inogona kunge ichipfuura miedzo yemakonzo nekuda kwekuti mbeva dzinogona kugadzirisa kukuvara kwesero nekukurumidza kuti masayendisiti aone.
Kusvikira mushonga iwoyo wabvumidzwa kushandiswa nevanhu uye vanhu vanga vachiutora kwemakore mazhinji ndipo mhedzisiro yenguva refu inotanga kuoneka. Izvi zvinotsanangura kuti nei mishonga yakawanda ichiyeukwa makore mazhinji gare gare mushure mekutenderwa.
Panguva iyoyo, nguva yapera! Hupenyu hwakarasika, mushonga unoyeukwa, uye FDA inoti "oops"!
Ipapo kutenderera kunodzokorora!
Zvinhu zvakaipa izvo FDA yakabvumidza - Chilling mienzaniso
Kune akawanda FDA akatenderwa mishonga yaimboonekwa yakachengeteka uye inoshanda iyo yava kuzivikanwa kuva inouraya.
Rondedzero yekutadza kweFDA yakarebesa asi heino mimwe mienzaniso inotyisa ingangove yakakonzerwa neiyo genetic anomalies mukuyedza mhuka.
Heano mamwe enjodzi dzakaipisisa dzemishonga munhoroondo…
Cerivastatin kubvisa
Mushonga wakadya vanhu vari vapenyu:
Imwe yemishonga ine ngozi yakatenderwa neFDA yaive cerivastatin, inozivikanwawo nezita rayo rechiratidzo Lipobay, iro raive rekugadzira statin.
Statins inonyorerwa pasi rose sekirasi yakajairika yemishonga inoshandiswa kuderedza cholesterol muvanhu vari panjodzi yechirwere chemoyo. MuUS, vanachiremba vanogara vachiraira 200 mamiriyoni statins gore negore.
Lipobay yakatengeswa nekambani yemishonga yeBayer mukupera kwema1990. Yakabviswa pamusika wepasi rose muna 2001 nekuda kwehuwandu hwekufa. Zvakaonekwa kuti vazhinji vevakafa vaive nerufu rhabdomyolysis zvinokonzerwa nemushonga. Rhabdomyolysis chirwere chinotyisidzira hupenyu chinokonzerwa nekukurumidza kuparara kwemhasuru.
Lipobay yaitoita kuti nyama dzevarwere dziparare!
Kana nyama yemhasuru ikaputswa, inoburitsa puroteni inonzi myoglobin muropa iyo itsvo dzinofanira kubvisa. Muhuwandu hukuru, itsvo hadzigone kusefa myoglobin nekukurumidza, izvo zvinogona kukonzera kukuvara kweitsvo, uye mumatambudziko akaomarara, kutadza kweitsvo uye kufa.
Rufu rwakawanda pakati pevarwere veLipobay rwakakonzerwa nerhabdomyolysis uye kukundikana kweitsvo. Zvakaonekwa kuti rhabdomyolysis inokonzerwa nema statins yaive 16 kune 80 nguva yakakwirira yeLipobay ichienzaniswa nemamwe ma statins.
Izvi zvakaitika sei?
Tinogona kungofungidzira, asi zvine musoro kugumisa kuti uku kuparara kwemhasuru kwakakurumidza hakuna kumboonekwa panguva yekuedzwa kwemhuka nevanhu. Iyo inouraya mhedzisiro haina kucherechedzwa kusvika makore gare gare Lipobay yatenderwa.
Miedzo yemakiriniki pavanhu ingangove yakafamba zvakanaka sezvo nguva yaive ipfupi kuti utarise izvi. Nekudaro, pamwe iyo rhabdomyolysis ingadai yakaratidza mumakonzo miedzo nekuda kwekukurumidza kutenderera kwehupenyu.
Nehurombo, mbeva dzema lab dzine matelomeres akareba zvisina kufanira aizogadzirazve tsandanyama uye kukuvara kweitsvo nekukurumidza zvekuti mhedzisiro iyi inogona kusaonekwa.
Iyi ngwavaira ingagona kudziviswa here kudai kuedza kwemhuka kwaiitwa pamakonzo “enguva dzose” uye kwete ma<em>motants akaberekeswa murabhoritari?
Ndiwo muenzaniso mumwechete, kune akawanda, akawanda akawanda FDA akabvumidzwa mishonga yakatadza.
Vioxx nharo
Pane runyorwa rurefu rwemishonga yakarangarirwa yaifanirwa kunge isina kumbobvira yasvika pamusika.
Imwe yemishonga yakakurumbira inoyeuka yaive rofecoxib, inowanzozivikanwa se Vioxx, nonsteroidal anti-inflammatory drug (NSAID) inoshandiswa kurapa arthritis uye kurwadziwa kwakanyanya. Vioxx yakayeukwa nekuda kwemishumo yekukuvadzwa kwemoyo izvo zvakakonzera kuwanda kwenjodzi yekurova kwemoyo uye sitiroko.
Zvingangove Vioxx yakakonzera kukuvadzwa kwesero kunhengo zhinji dzemuviri asi yaionekwa sekukuvadzwa kwemoyo nekuti masero emoyo ane hurombo hwakanyanya hwekuita patsva.
Kukuvadzwa kwesero kwakakonzerwa naVioxx kwaifanira kunge kwaonekwa panguva yekuyedzwa kwemakonzo, asi nekuda kwechimwe chikonzero, haina kuoneka.
Bextra remember
Mushonga wakafanana kuVioxx pane iyo FDA yekuyeuka runyorwa ndeye valdecoxib, inowanzozivikanwa nezita rayo rekuti Bextra. SaVioxx, Bextra yaive imwe NSAID yaishandiswa kurapa arthritis.
Bextra yakabvumidzwa munaNovember 2001 neFDA. Yakazoyeukwa muna Kubvumbi 2005, anenge makore mana gare gare. Iyo FDA yakataura zvikonzero zvekuyeuka kuve "inogona kuwedzera njodzi yezvakakomba zvemoyo (CV) zviitiko zvakashata" uye "kuwedzera kwenjodzi yekukanganiswa kweganda", kusanganisira. Stevens-Johnson syndrome.
Kuyeuka kwaBextra kwakaguma nefaindi hurusa yeutsotsi yerudzi rwupi norwupi!
Kambani yezvinodhaka Pfizer aifanira kubhadhara vakabvisa rekodhi rekodhi $1.3 bhiriyoni yefaindi yekutadza kutengesa mushonga "nechinangwa chekubiridzira kana kutsausa". Pfizer aifanirawo kubhadhara bhiriyoni imwe yemadhora mukukuvadzwa kwevanhu.
Ingosiya chokwadi ichi chinyure mukati ...
Faindi hurusa yati yambobhadharwa munhau yakaitwa nekambani yezvinodhaka!
Rezulin rangarira
Zvakare pane rondedzero yekutadza kukuru kweFDA…
Troglitazone, zita rechiratidzo Rezulin, yakashandiswa kurapa chirwere cheshuga uye yaiva imwe nyaya yemushonga wakakonzera kukanganisa nhengo. Kunyanya, Rezulin yakakonzera kukuvara kwechiropa.
Pakutanga, mushure memishumo yakawanda yekukasira kukundikana kwechiropa muvarwere vanotora mushonga, iyo FDA yakapa yambiro inoda kuongororwa kwemwedzi wega wega mazinga ee enzyme muvarwere.
Izvi zvinokatyamadza:
Pakatozosvikira murwere ane makore makumi mashanu neshanu okuberekwa afa nekutadza kwechiropa kwakanyanya mushure mekutora Rezulin sechikamu cheongororo yakatariswa neNational Institutes of Health (NIH) iyo yakabvunzwa kana kuongorora mazinga ee enzyme kwaikwana.
Iyo NIH yakadonhedza mushonga kubva muchidzidzo, uye nguva pfupi yakatevera chiremba weFDA uyo akaongorora Rezulin akafungidzira kuti inogona kuve yakabatana nekudarika mazana mana nemakumi matatu ekutadza kwechiropa. Vakaona kuti varwere vane a 1,200 nguva njodzi huru yekukundikana kwechiropa paunotora mushonga.
Musi waKurume 21, 2000, iyo FDA yakazorangarira Rezulin mushure mekunge yave pamusika kweanopfuura makore matatu.
Kubviswa kweRezulin kungave kwakadzivirirwa here kana kukuvara kwechiropa kwakaonekwa panguva yekuedzwa kwemakonzo?
Mishonga iyi ingori sampuli diki yerondedzero refu yeFDA yakatenderwa mishonga yakazoyeukwa, asi inoratidza kuti mishonga inotenderwa sei uye yozoyeukwa makore mazhinji gare gare (uye hupenyu huzhinji gare gare) apo mhedzisiro yenguva refu inotanga kudzoreredza yakashata. musoro.
Muchidimbu:
Chero chiitiko chinosuwisa chemushonga chiri kurangarirwa nekuda kweimwe nzira yekukuvadzwa kwenhengo/tishu ingadai yakadzivirirwa dai kuyedzwa kwemakonzo kwaitwa pamarudzi akajairwa. Kubva pakuona kwekuongorora zvinodhaka, mbeva nemakonzo madiki zvinhu zvakakosha asi kana zvakamiririra zvisikwa.
Kuita kuti zvinhu zviwedzere…
Zvakadini nenhamba yemishonga inogona kubatsira inogona kunge yakaraswa nekuti yaionekwa sekuwedzera kenza njodzi mumakonzo akange atofanotemerwa cancer!?
Ndinofunga hatizombofi takaziva mhinduro yemubvunzo iwoyo.
Mishonga haina ngozi here? - Chii chatingaita zvino?
Shoko racho rakajeka:
Maitiro ese ekuongorora kushanda kwezvinodhaka uye kuchengetedzeka akakanganisa zvakanyanya. Sainzi yeindasitiri yemishonga yakaora!
Kunyangwe pasina kuziva sainzi, kungotarisa kuti mangani madhiragi akatenderwa neFDA akarangarirwa humbowo hwakajeka hwekuti chimwe chinhu chakashata.
Zvinosuruvarisa, pane rondedzero yakakura yeFDA yakatenderwa mishonga inouraya uye yakaparadza mhuri.
Hazvina maturo kutaura, sainzi yave ichibatsira zvikuru kurudzi rwomunhu, asi haina kukwana, kana kuti zvichida nomutoo wakarurama zvikuru, masayendisiti haana kukwana. Kubvunza sainzi hakuite iwe "anti-sainzi", kunokuita iwe pro-sainzi nekuti ndizvo zviri maererano nesainzi.
Masayendisiti anobvunza tsvakiridzo yapfuura, vanoita hypothesis vobva vaiedza. For evanhu vezvenhau makambani nehurumende kudaidza vanhu kuti "anti-sainzi" pavanobvunza a vaccine efficacy tsananguro inopenga. Ndiko “kupokana nesainzi”!
Zvichida vatsvakurudzi vanofanira kunge vakafungidzira kuti mapurogiramu makuru ekurera makonzo anogona kukonzera kusiyana kwemajini kwaisazoitika mumasikirwo, asi chakakosha iko zvino kubvuma chikanganiso nekuchigadzirisa.
Zvakadaro muindasitiri inotungamirwa nepurofiti, Big Pharma inovimbika zvakakwana kuti ibvume zvikanganiso?
Nehurombo, mhinduro ndeyokuti kwete, uye zviri pachena kubva mukukundikana kweFDA kwakapfuura kuti makambani ezvinodhaka achaita chero chinhu musimba rawo kudzivirira kurangarira kukuru. Vanoda kuti "ndine urombo" uye kubhadhara nhamba shoma yekukuvadza kune vakakuvadzwa pane kubvuma uye kubvisa nyaya yakakosha.
Panogona kunge paine mazana, kunyangwe zviuru zvemishonga ine njodzi yakatsvedza mumambure nekuda kwekukanganisa kwemakonzo. Kuedzazve kuongorora uye kugona kurangarira ukuru kunogona kukanganisa kambani yese yezvinodhaka pasirese - asi hutano hwevarwere hunonyanya kukosha!
Asi chii chaungaite?
Ruzivo isimba, uye kudzidzisa veruzhinji nevatapi venhau nezvesainzi kuseri kwenyaya iyi inhanho yekutanga. Nevanhu vakakwana vane ruzivo, vagadziri vemitemo vanogona kupedzisira vateerera, uye kupindira kwehurumende kunogona kuitika.
Zvapera kwauri, hauna simba, internet inopa munhu wese izwi rinogona kusvika kumamiriyoni. Ipa chinyorwa ichi SHARE, udza munhu wese waunoziva, uye usamire kusvika zvinhu zvachinja.
"Iva shanduko yaunoda kuona munyika!"
Tinoda rubatsiro RWENYU! Tinokuunzirai nhau dzisina kudzivirirwa dze FREE, asi isu tinogona chete kuita izvi nekuda kwerutsigiro rwevaverengi vakavimbika sezvakangoita IWE! Kana iwe uchitenda mukutaura kwemahara uye uchinakidzwa nenhau chaidzo, ndapota funga kutsigira chinangwa chedu ne kuva mutsigiri kana nekuita a imwe-off donation pano. 20% ye ALL mari inopihwa veterans!
By Richard Ahern - LifeLine Media
Contact: Richard@lifeline.news
Yakabudiswa:
Last Updated:
References (chokwadi-cheki vimbiso):
- FDA Drug Recall Statistics: https://www.maylightfootlaw.com/blogs/fda-drug-recall-statistics/ [Nhamba yepamutemo]
- Deoxyribonucleic Acid (DNA): https://www.genome.gov/genetics-glossary/Deoxyribonucleic-Acid [Webhusaiti yeHurumende]
- Mitosis / cell division: https://www.nature.com/scitable/definition/mitosis-cell-division-47/ [Chinyorwa chedzidzo/saiti]
- Nyaya yeJunk DNA: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4014423/ [Chinyorwa chedzidzo/saiti]
- Telomeres, mararamiro, kenza, uye kukwegura: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3370421/ [Peer-yakaongororwa bepa rekutsvagisa]
- Iyo Hayflick Limit: https://embryo.asu.edu/pages/hayflick-limit#:~:text=The%20Hayflick%20Limit%20is%20a,programmed%20cell%20death%20or%20apoptosis. [Chinyorwa chedzidzo/saiti]
- Senescence uye kuchembera: Zvinokonzera, mhedzisiro, uye nzira dzekurapa: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5748990/ [Peer-yakaongororwa bepa rekutsvagisa]
- Environmental Mutagens, Cell Signaling uye DNA Kugadzirisa: https://www.nature.com/scitable/topicpage/environmental-mutagens-cell-signalling-and-dna-repair-1090/ [Chinyorwa chedzidzo/saiti]
- Hypervariable ultra-long telomeres mumakonzo: https://www.nature.com/articles/347400a0 [Peer-yakaongororwa bepa rekutsvagisa]
- Bret Weinstein pa "The Portal" (w/ host Eric Weinstein), Ep. #019 - Kufanotaura uye iyo DISC: https://www.youtube.com/watch?v=JLb5hZLw44s [Kubva kwaibva]
- Wild-derived inbred mouse strains ane mapfupi telomeres: https://pubmed.ncbi.nlm.nih.gov/11071935/ [Peer-yakaongororwa bepa rekutsvagisa]
- Iyo reserve-capacity hypothesis: evolutionary mabviro uye zvazvino zvinokonzeresa zvekutengeserana-kubvisa pakati pebundu-kudzvinyirira uye kugadzirisa-matishu: https://www.gwern.net/docs/longevity/2002-weinstein.pdf [Peer-yakaongororwa bepa rekutsvagisa]
- Alexander, P., 1966. Pane hukama here pakati pekuchembera, kupfupikiswa kwehupenyu-refu nemwaranzi uye kuiswa kwe somatic mutations?: Maonero muKuedza Gerontology. mapeji 266-279. [Peer-yakaongororwa bepa rekutsvagisa]
- Varume nembeva: Zvinoenderana nezera ravo: https://pubmed.ncbi.nlm.nih.gov/26596563/ [Peer-yakaongororwa bepa rekutsvagisa]
- Cerivastatin: https://pubchem.ncbi.nlm.nih.gov/compound/Cerivastatin [Chinyorwa chedzidzo/saiti]
- Mafambiro eNyika muKushandiswa kweStatin uye Kushandiswa kwemari muUS Vakuru Vagari Kubva 2002 kusvika 2013: https://jamanetwork.com/journals/jamacardiology/fullarticle/2583425 [Nhamba yepamutemo]
- Rhabdomyolysis: Pathogenesis, Kuongororwa, uye Kurapa: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4365849/ [Peer-yakaongororwa bepa rekutsvagisa]
- Clinical pharmacological explanatory modhi ye cerivastatin-yakabatana rhabdomyolysis: https://onlinelibrary.wiley.com/doi/abs/10.1046/j.1563-258X.2003.03029.x [Chinyorwa chedzidzo/saiti]
- Vioxx (rofecoxib) Mibvunzo neMhinduro: https://www.fda.gov/drugs/postmarket-drug-safety-information-patients-and-providers/vioxx-rofecoxib-questions-and-answers#:~:text=Vioxx%20is%20a%20COX%2D2,3. [Webhusaiti yeHurumende]
- Valdecoxib: https://en.wikipedia.org/wiki/Valdecoxib [Chiremera chepamusoro uye webhusaiti yakavimbika] {Kumwe kuverenga}
- Stevens-Johnson syndrome / chepfu epidermal necrolysis: https://rarediseases.info.nih.gov/diseases/7700/stevens-johnson-syndrometoxic-epidermal-necrolysis [Webhusaiti yeHurumende]
- US v. Pfizer, Inc. – Chibvumirano Chekugadzirisa: https://www.justice.gov/usao-ma/press-release/file/1066111/download [gwaro redare repamutemo]
- Rezulin: https://www.accessdata.fda.gov/drugsatfda_docs/label/1999/20720s12lbl.pdf [Webhusaiti yeHurumende]
- Troglitazone: https://en.wikipedia.org/wiki/Troglitazone [Chiremera chepamusoro uye webhusaiti yakavimbika] {Kumwe kuverenga}
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